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Single cell multimodal analysis and machine learning define haematopoietic progenitor and HSC-like cells derived in vitro from human pluripotent stem cells.
Fidanza et al., 2020, Blood
A novel human pluripotent stem cell-based gene activation system identifies IGFBP2 as a mediator in the production of hematopoietic progenitors in vitro
Petazzi et al., 2024, eLife
 
scRNA-seq

Day 13 suspension cells

CRISPRa

CRISPR-activated cells

CITE-seq

Day 10+13 suspension cells

IGFBP2

IGFBP2-treated cells

CITE-seq + label transfer

Day 10+13